C-reactive protein: not always a reliable marker of ongoing cytokine release syndrome in CAR-T therapy following IL-6 blockade

Jonathan SiglinUniversity of Maryland School of Medicine, Baltimore, MD, USA;

Ali BukhariMarlene and Stewart Greenebaum Comprehensive Cancer Center, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA;

Forat LutfiMarlene and Stewart Greenebaum Comprehensive Cancer Center, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA;

Noa G. HoltzmanMarlene and Stewart Greenebaum Comprehensive Cancer Center, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA;

Carl ShanholtzUniversity of Maryland School of Medicine, Baltimore, MD, USA; ;Division of Critical Care, University of Maryland School of Medicine, Baltimore, MD, USA

Jean A. YaredMarlene and Stewart Greenebaum Comprehensive Cancer Center, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA;

Nancy M. HardyMarlene and Stewart Greenebaum Comprehensive Cancer Center, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA;

Aaron P. RapoportMarlene and Stewart Greenebaum Comprehensive Cancer Center, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA;

Saurabh DahiyaMarlene and Stewart Greenebaum Comprehensive Cancer Center, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Correspondence[email protected]

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Acknowledgements

We appreciate the outstanding work of the cellular processing laboratory at the University of Maryland Greenebaum Comprehensive Cancer Center as well as the supporting nurses, technicians, and additional providers in the Bone Marrow Transplant department.

Author contributions

SD identified the described cases. JS wrote the manuscript with assistance from FL, AB, and SD. All authors provided critical feedback and were involved in the writing of manuscript.

Disclosure statement

None of the authors have any relevant conflicts of interest to disclose.

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C-reactive protein: not always a reliable marker of ongoing cytokine release syndrome in CAR-T therapy following IL-6 blockade

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C-reactive protein: not always a reliable marker of ongoing cytokine release syndrome in CAR-T therapy following IL-6 blockade

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