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Original Articles

Balanced and unbalanced chromosomal translocations in myelodysplastic syndromes: clinical and prognostic significance

Sara Mohameda Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Roberto Latagliataa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Maria Zaira Limongia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Stefania Nigroa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Eleonora Sangiorgia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Mauro Nannia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Annalina Piccionib Hematology, Azienda Ospedaliera S. Giovanni-Addolorata, Rome, Italy

Alessia Campagnac Hematology, Sant’Andrea Hospital Sapienza University of Rome, Rome, Italy

Maria Antonietta Aloe Spiritic Hematology, Sant’Andrea Hospital Sapienza University of Rome, Rome, Italy

Ida Carmosinoa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Matteo Molicaa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Elena Mariggiòa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Serena Rosatia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Gioia Colafiglia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Francesca Fazioa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Maria Lucia De Lucaa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Daniela De Benedittisa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Emilia Scalzullia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Massimo Brecciaa Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy

Marco Mancinia Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, ItalyCorrespondence[email protected]

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Abstract

Prognostic role of chromosomal translocations (CT) in myelodysplasia (MDS) was retrospectively analyzed in 77 patients from GROM-L registry. Forty (51.9%) balanced, 28 (36.4%) unbalanced and 9 (11.7%) concomitant balanced and unbalanced CT were identified. Five-year overall survival (OS) of the entire cohort was 34.5% (CI 95% 22.5−46.5). Five-year OS of patients with unbalanced CT was significantly shorter than that of patients carrying balanced CT [22.3% (CI 95% 4.0−40.6) vs 44.0% (CI 95% 26.7−61.3) (p = 0.042)]. Five-year OS of patients with CT included in complex karyotype (CK) was significantly shorter than that of patients with isolated CT or CT with another abnormality [5.5% (CI 95% 0−15.7) vs 42.9% (CI 95% 21.3−64.5) and vs 4% (CI 95% 31.6−79.2) (p < 0.001)]. Presence of CT in MDS characterizes a more aggressive outcome only when associated with CK.

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Ethical approval

All procedures performed in the present study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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No potential conflict of interest was reported by the author(s).

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Balanced and unbalanced chromosomal translocations in myelodysplastic syndromes: clinical and prognostic significance

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Balanced and unbalanced chromosomal translocations in myelodysplastic syndromes: clinical and prognostic significance

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