Exploration of whole genome and transcriptome sequencing data lacks evidence for oncogenic viral elements to drive the pathogenesis of T-cell prolymphocytic leukemia

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Acknowledgements

The authors thank the members of the cancer genetics laboratories of the Institutes of Human Genetics in Ulm and Kiel for expert support and discussion. We gratefully acknowledge contributing centers for enrolling all patients. The author thank the Omics IT and Data Management Core Facility of the German Cancer Research Center (DKFZ) for excellent technical support.

Author contributions

MH provided the WGS data of three T-PLL patient samples and reviewed the manuscript. UHT, JS, and MS performed bioinformatic analyses of WGS data. SHB did the bioinformatic analysis of mRNA data. TB coordinated the EBV PCR verification experiments. LW and PL reviewed the paper. MZ performed the bioinformatic analysis for detection of the viral pathogens, interpreted the data and reviewed the paper. PP: performed data analysis, interpreted the data, and wrote the manuscript. RS designed and developed the study, provided intellectual input, and reviewed the paper.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by grants of the German Research Foundation (DFG) in the framework of the Collaborative Research Centre SFB 1074 (Projects B1 and B9N/B9). MH was supported by the EU Transcan-2 Consortium ERANET-PLL and by the ERAPerMed Consortium JAKSTAT-TARGET.