Distinct immune-response profile of Richter transformation chronic lymphocytic leukemia (CLL), defined by high expression of PD1, LAG3, TIM3 and IL-10

Amir Behdada Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;c Department of Medicine (Hematology and Oncology), Northwestern University Feinberg School of Medicine, Chicago, IL, USACorrespondence[email protected]

Matthew John Schipmab Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Shuo Mac Department of Medicine (Hematology and Oncology), Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Yi-Hua Chena Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Qing Ching Chena Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

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Acknowledgements

The authors acknowledge all the patients that were included in the study. The authors are thankful to David Dittmann for his help with next-generation sequencing.

Author contributions

QC, and AB designed the study, collected and analyzed data, wrote the manuscript, and approved the final version. MS analyzed data and helped with the manuscript. YC and SM revised the manuscript and approved the final version.

Disclosure statement

AB has received honorarium for speaker bureau from Eli Lilly, Foundation Medicine/Roche China, Thermo Fisher scientific and Bayer. SM has Research Funding: Loxo; AstraZeneca; Juno; BeiGene; Abbvie; Janssen; TG Therapeutics; Pharmacyclics; Consultancy: AstraZeneca; Abbvie, BeiGene, Janssen, TG Therapeutics; Speakers Bureau: AstraZeneca; BeiGene; Janssen; Pharmacyclics.

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Distinct immune-response profile of Richter transformation chronic lymphocytic leukemia (CLL), defined by high expression of PD1, LAG3, TIM3 and IL-10

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Distinct immune-response profile of Richter transformation chronic lymphocytic leukemia (CLL), defined by high expression of PD1, LAG3, TIM3 and IL-10

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