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Leukemia & Lymphoma Volume 64, 2023 - Issue 2
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Letters to the Editor

Successful treatment of severe cytokine release syndrome after CAR-T therapy by ruxolitinib without compromising CAR-T efficacy

Chengyuan Gua National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China;b Institute of Blood and Marrow Transplantation, Suzhou, China;c Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaView further author information
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Qian Wua National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China;b Institute of Blood and Marrow Transplantation, Suzhou, China;c Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaView further author information
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Jingren Zhanga National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China;b Institute of Blood and Marrow Transplantation, Suzhou, China;c Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaView further author information
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Liqing Kangd School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China;e Shanghai Unicar-Therapy Bio-medicine Technology Co., Ltd, Shanghai, ChinaView further author information
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Lei Yud School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China;e Shanghai Unicar-Therapy Bio-medicine Technology Co., Ltd, Shanghai, ChinaView further author information
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Huiying Qiua National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China;b Institute of Blood and Marrow Transplantation, Suzhou, China;c Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaView further author information
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Depei Wua National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China;b Institute of Blood and Marrow Transplantation, Suzhou, China;c Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaView further author information
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Suning Chena National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China;b Institute of Blood and Marrow Transplantation, Suzhou, China;c Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaView further author information
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Xiaofei Yanga National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China;b Institute of Blood and Marrow Transplantation, Suzhou, China;c Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaCorrespondence[email protected]
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Pages 495-498 | Received 03 May 2022, Accepted 11 Nov 2022, Published online: 17 Nov 2022
 
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Author contributions

Chengyuan Gu and Qian Wu contributed to manuscript preparation, data acquisition, and clinical treatment. Jingren Zhang contributed to the collection of clinical data and clinical treatment. Liqing Kang and Lei Yu contributed to CAR-T cell preparation. Depei Wu contributed to data acquisition and interpretation and design. Xiaofei Yang and Suning Chen contributed to the study design, data analysis, and manuscript revision.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors thank all members of the study team, the patients, and their family. This work was supported by research grants from the National Natural Science Foundation of China [81730003], National Science and Technology Major Project [2017ZX093040 21], National Key R&D Program of China [2019YFC0840604, 2017YFA0104502], National Natural Science Foundation of Jiangsu Province [BE2018652], Key R&D Program of Jiangsu Province [BE2019798], Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Jiangsu Medical Outstanding Talents Project [JCRCA2016002], Jiangsu Provincial Key Medical Center [YXZXA2016002], Suzhou Science and Technology Program Project [SLT201911].

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