Wilms’ tumor 1 expression combined with genetic mutations for prognostic assessment in MDS

Abstract

Overexpression of Wilms’ tumor (WT1) is frequently observed in myelodysplastic syndrome (MDS), which has been proposed as a prognostic marker. However, the prognostic role of WT1 expression in different contexts remains to be fully elucidated. We retrospectively assessed the relationships between WT1 levels and preexisting prognostic factors to further investigate its prognostic role under different contexts. In our study, WT1 expression was positively correlated with WHO 2016 classification and IPSS-R stratification. Lower WT1 expression was found in relation to TET2, TP53, CD101, or SRSF2 mutations, while mutant NPM1 patients possessed higher level. Notably, WT1 overexpression maintained its inferior prognostic effect on overall survival (OS) in TP53-wild patients but not in TP53-mutated group. In multivariate analysis, higher WT1 expression was a risk factors for OS in EB patients without TP53 mutations. Overall, WT1 expression was useful to predict prognosis for MDS and its prognostic role was impacted by some gene mutations.

Keywords:

• Myelodysplastic syndromes
• Wilms’ tumor 1
• prognosis biomarker
• gene mutations

Acknowledgements

We sincerely thank all colleagues in the Department of Hematology, Nanfang Hospital, for their help in this study. All authors critically revised the manuscript.

Ethical approval

This study was conducted in accordance with the modified Helsinki Declaration and the protocol was approved by the ethical review boards of Nanfang Hospital, Southern Medical University (Ethical approval No. NCT02850822).

Consent form

All patients gave their permission to use clinical information relating to this study and written informed consent.

Author contributions

Danqi Pan collected data, analyzed data, and prepared the manuscript. Wenshu Zhao helped collecting data and performing the analyses with constructive discussions. Qianli Jiang, Changxin Yin, Han He, Libin Liao, and Jieyu Ye contributed to carrying out related analysis and finalizing this paper. Min Dai conceived of the research, designed the research and revised the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

Data used to support the findings of this study are available from the corresponding author upon request.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.