Author contributions
DF and EK performed data analysis and research design and wrote the paper. FT, PM, INS, MG, NK, MM and EEP were involved in data collection and patient management and reviewed the manuscript. ET and MAD reviewed the manuscript. AP and CK reviewed the majority of the pathology specimens and reviewed the manuscript.
Disclosure statement
Conflicts of interest EK: Consultancy: Janssen, Pfizer, Amgen Honoraria: Janssen, Pfizer, Takeda, Genesis Pharma, Amgen MG; Honoraria: Janssen, Genesis Pharma, Amgen, Karyopharm, Sanofi, GSK, Takeda, ET; Consultancy: Janssen, Amgen, Genesis Pharma, Celgene, Takeda, Sanofi; Honoraria: Novartis, Janssen, Takeda, Genesis Pharma, Amgen, Celgene, Sanofi, BMS, GSK; MAD: Honoraria: Takeda, BMS, Amgen, Beigene, Janssen. DF, FT, MG, MM, NK, PM, INS, EEP, AP, CK declare no conflicts of interest.