Hereditary alpha-tryptasemia and complete deletion of exon 8 of the c-kit gene in patients with mast cell activation syndrome

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Ethical approval

This case series was conducted ethically in accordance with the World Medical Association Declaration of Helsinki. This study protocol was reviewed and approved by the St. Michael’s Hospital Research Ethics Board, approval number 11-088. Written consent to participate in the case series was obtained from all participants.

Acknowledgements

The authors thank Dr. Lisa Hicks in the Division of Hematology, Oncology at St. Michael’s Hospital for her assistance with the clinical care of these patients and for her review of our manuscript.

Author contributions

M.J. performed the literature review, chart review, and wrote the manuscript. P.V. was involved directly in the clinical care of the patients in the case series, supervised the work, and assisted with manuscript preparation. All authors critically revised the manuscript and gave final approval for the version to be published.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data that support the findings of this study are not publicly available due to it containing information that could compromise the privacy of research participants but are available from the corresponding author M.J. upon reasonable request.

Additional information

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.