Peripheral Progenitor Cells (CFU-GM, BFU-E, CD34) Are Increased in Untreated Chronic Lymphocyte Leukemia Patients: Stage B and C Display a Particularly High CD34⁺ Cell Count

Marc Berger Secteur d'Etude en HEMatopoièse, laboratoire d'Hématologic, 28 Place Henri Dunant, BP 38, 63001, Clermont-Ferrand, Cedex, France

Chantal Rapatel Secteur d'Etude en HEMatopoièse, laboratoire d'Hématologic, 28 Place Henri Dunant, BP 38, 63001, Clermont-Ferrand, Cedex, France

Nathalie Boiret Secteur d'Etude en HEMatopoièse, laboratoire d'Hématologic, 28 Place Henri Dunant, BP 38, 63001, Clermont-Ferrand, Cedex, France

Pascale Halle Secteur d'Etude en HEMatopoièse, laboratoire d'Hématologic, 28 Place Henri Dunant, BP 38, 63001, Clermont-Ferrand, Cedex, France

Justyna Kanold Secteur d'Etude en HEMatopoièse, laboratoire d'Hématologic, 28 Place Henri Dunant, BP 38, 63001, Clermont-Ferrand, Cedex, France

Gabrielle Mareynat Secteur d'Etude en HEMatopoièse, laboratoire d'Hématologic, 28 Place Henri Dunant, BP 38, 63001, Clermont-Ferrand, Cedex, France

Olivier Tournilhac Secteur d'Etude en HEMatopoièse, laboratoire d'Hématologic, 28 Place Henri Dunant, BP 38, 63001, Clermont-Ferrand, Cedex, France

Eliane Albuisson Secteur d'Etude en HEMatopoièse, laboratoire d'Hématologic, 28 Place Henri Dunant, BP 38, 63001, Clermont-Ferrand, Cedex, France

Jean Bonhomme Secteur d'Etude en HEMatopoièse, laboratoire d'Hématologic, 28 Place Henri Dunant, BP 38, 63001, Clermont-Ferrand, Cedex, France

Francois Deméocq Secteur d'Etude en HEMatopoièse, laboratoire d'Hématologic, 28 Place Henri Dunant, BP 38, 63001, Clermont-Ferrand, Cedex, France

Philippe Travade Secteur d'Etude en HEMatopoièse, laboratoire d'Hématologic, 28 Place Henri Dunant, BP 38, 63001, Clermont-Ferrand, Cedex, France

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Abstract

No treatment has proved its efficiency in CLL. Autologous transplantation is now under consideration for the youngest patients. We assayed progenitor cells (CFU-GM, BFU-E, CD34) in the peripheral blood of 28 untreated CLL patients and found an increase of all these progenitors in CLL compared to controls. There was no statistical difference between stage A versus stages B and C for CFU-GM and BFU-E. In contrast, CD34 cells were higher in stages B and C as compared to stage A. This finding could be explained by a high number of circulating clonal cells in advanced stages of the disease.

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Peripheral Progenitor Cells (CFU-GM, BFU-E, CD34) Are Increased in Untreated Chronic Lymphocyte Leukemia Patients: Stage B and C Display a Particularly High CD34⁺ Cell Count

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Peripheral Progenitor Cells (CFU-GM, BFU-E, CD34) Are Increased in Untreated Chronic Lymphocyte Leukemia Patients: Stage B and C Display a Particularly High CD34+ Cell Count

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Peripheral Progenitor Cells (CFU-GM, BFU-E, CD34) Are Increased in Untreated Chronic Lymphocyte Leukemia Patients: Stage B and C Display a Particularly High CD34⁺ Cell Count