Non-Hodgkin's Lymphoma Followed by Plasmacytoma, Both Arising in a Thyroid Gland with Hashimoto's Disease

Y. Hasegawa Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Japan

T. Itoh Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Japan

Y. Tamagawa Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Japan

T. Komeno Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Japan

H. Kojima Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Japan

H. Ninomiya Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Japan

Y. Yatabe Division of First Pathology, School of Medicine, University of Nagoya, Japan

N. Mori Division of First Pathology, School of Medicine, University of Nagoya, Japan

T. Nagasawa Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Japan

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Abstract

We describe here a rare case of malignant lymphoma followed by plasmacytoma in Hashimoto's thyroiditis. The patient developed malignant lymphoma (small, non-cleaved cell, and non Burkitt's type by Working Formulation classification), and remained in remission for 2 years after receiving combination chemotherapy, and then developed plasmacytoma in the same lesion. Rearrangement bands for IgH from both specimens showed different bands, indicating that both were of monoclonal type but of a different clonal origin.

Considering the clinical course in this case, thyroidectomy may be indicated for Iymphoproliferative diseases in Hashimoto's thyroiditis treated with chemotherapy.

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Non-Hodgkin's Lymphoma Followed by Plasmacytoma, Both Arising in a Thyroid Gland with Hashimoto's Disease

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Non-Hodgkin's Lymphoma Followed by Plasmacytoma, Both Arising in a Thyroid Gland with Hashimoto's Disease

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