BIOLOGICALLY BASED KINETIC MODEL FOR CHEMICAL KINETICS IN THE ISOLATED PERFUSED RAT LIVER SYSTEM: BASIC RECIRCULATION MODEL FOR WATER-SOLUBLE/LIPID-INSOLUBLE CHEMICALS

Abstract

The isolated perfused rat liver preparation is a useful experimental tool to study the role of the liver in controlling the systemic kinetics of chemicals in mammalian systems. Various kinetic processes can influencechemical behavior in the isolated perfused rat liver, including membranetransport, binding, metabolism, and biliary excretion. A generic biologically based kinetic model that incorporates these processes is described. The model is for water-soluble/lipid-insoluble chemicals, i.e., chemicals that do not accumulate in the lipid phase. Several theoretical examples of the kinetic behavior of chemicals with particular properties areused toillustratetheflexibility of themodel.Themodel can beused toanalyze the kinetics of chemicals of interest and as an educational tool to understand the kinetic implications of the interactions of various physiological-biochemical processes.

Keywords: :

• Isolated Perfused Liver Biologically Based Kinetic Modeling Water Soluble Chemicals