https://orcid.org/0000-0002-0890-769X
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Abstract
Primary Objective
The primary objective of the review is to assess the potential of lymphatic-targeted drug delivery systems, with a particular emphasis on their role in tumour therapy and vaccination efficacy.
Reason for Lymphatic Targeting
The lymphatic system’s crucial functions in maintaining bodily equilibrium, regulating metabolism, and orchestrating immune responses make it an ideal target for drug delivery. Lymph nodes, being primary sites for tumour metastasis, underscore the importance of targeting the lymphatic system for effective treatment.
Outcome
Nanotechnologies and innovative biomaterials have facilitated the development of lymphatic-targeted drug carriers, leveraging endogenous macromolecules to enhance drug delivery efficiency. Various systems such as liposomes, micelles, inorganic nanomaterials, hydrogels, and nano-capsules demonstrate significant potential for delivering drugs to the lymphatic system.
Conclusion
Understanding the physiological functions of the lymphatic system and its involvement in diseases underscores the promise of targeted drug delivery in improving treatment outcomes. The strategic targeting of the lymphatic system presents opportunities to enhance patient prognosis and advance therapeutic interventions across various medical contexts, indicating the importance of ongoing research and development in this area.
Graphical Abstract
Acknowledgment
“The author acknowledges the department of pharmaceuticals under the government of India. The NIPER/R/communication no 533”. The author (Prashant Kesharwani) acknowledges financial support from the Indian Council of Medical Research (ICMR), New Delhi, India, through Extramural Research Grants.
Disclosure statement
No potential conflict of interest was reported by the author(s).