Maternal Leptin Concentrations are Similar in African Americans and Caucasians in Normal Pregnancy, Preeclampsia and Small-for-Gestational-Age Infants

Laura D. Jenkins Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Departments of Family Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USACorrespondence[email protected]

Robert W. Powers Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Obstetrics & Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Mary Adotey Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Marcia J. Gallaher Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Nina Markovic Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Roberta B. Ness Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

James M. Roberts Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Obstetrics & Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

show all

Abstract

Leptin concentrations were measured in African American women in order to assess leptin's role in the increased frequency and severity of preeclampsia. In addition, leptin concentrations were measured in women who delivered small-for-gestational-age (SGA) infants. A case-control study of African American and Caucasian women with normal pregnancies, preeclampsia, or SGA infants was done. Plasma leptin was quantitated by radio-immunoassay. The previously recognized pattern of increased leptin concentrations in preeclampsia was replicated. Leptin concentrations did not differ by race in any diagnostic category, and concentrations in women with SGA infants were not higher than those in healthy women. Differences in the frequency and severity of preeclampsia in African Americans cannot be explained by higher leptin concentrations.

Keywords:

Notes

*Funded in part by National Institutes of Health grants NIH-5MO1-RR00056 and NIH-PO1-HD30367.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Maternal Leptin Concentrations are Similar in African Americans and Caucasians in Normal Pregnancy, Preeclampsia and Small-for-Gestational-Age Infants

Information for

Open access

Opportunities

Help and information

Maternal Leptin Concentrations are Similar in African Americans and Caucasians in Normal Pregnancy, Preeclampsia and Small-for-Gestational-Age Infants

Abstract

Notes

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature