Baroreflex Gain in Normotensive and GH Hypertensive Rats before and after Early Gonadectomy

Abstract

The authors have assessed arterial baroreflex gain in urethane-anesthetized normotensive and New Zealand genetically hypertensive (GH) rats and investigated the effect of gonadectomy in adult animals at 3 weeks of age postnatally. No gender differences in resting blood pressures existed for either normotensive or GH strains. In normotensive animals, bradycardic gain was greater than tachycardic gain and was lower in females than in males. Tachycardic gain was similar in GH and normotensive rats of either sex, but bradycardic gain was lower in GH. Gonadectomy had no effect on baroreflex gain in male or female animals of either strain.

Keywords:

• baroreflex
• estrogen
• testosterone
• GH
• New Zealand hypertensive rat
• gender