Chinese herbal medicine formula combined with calcium antagonist in the treatment of hypertension: a systematic review and meta-analysis

ABSTRACT

Objective: Chinese herbal medicine formula and calcium antagonist are commonly used medicines for hypertension in China. This study aims to examine the efficacy and safety of for the treatment of Chinese herbal medicine formula combined calcium antagonist hypertension. Methods: PubMed, the Cochrane library, CNKI, VIP, Sinomed, and Wanfang Database were searched up to January 31, 2021. Data analysis was performed using the Recman 5.3. The source of clinical heterogeneity used stata16.0 for sensitivity analysis. Results: 17 RCTs and 1587 cases were finally included. The results shows that the traditional Chinese medicine decoction combined with calcium antagonists is better than calcium antagonists alone in the treatment of hypertension. In addition, it can effectively alleviate the adverse reactions caused by calcium antagonists. However, due to the low quality of methodology and the small-scale research, more high-quality clinical trials are still needed for verification.

KEYWORDS:

• Hypertension
• traditional Chinese medicine
• calcium antagonist
• systematic evaluation
• meta-analysis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author contributions statement

Qingyuan Zhang conceived the research plan and completed the first draft. Yonghuan Xiao, Yaling Wang searched databases, managed the literature and extracted the data. Wenxiang Shao checked the extracted data and analyzed the data. Jingwen Zhang provided guidance for TCM theories. Meiying Ao completed the experimental design and execution.

Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Research registration

This research programme has been registered in INPLASY, and the registration number is INPLASY202160100.

Supplementary materials

Supplemental data for this article can be accessed on the publisher’s website.

Additional information

Funding

This research was supported by the National Natural Science Foundation of China [No. 82060658], 2021 National College Students Innovation and Entrepreneurship Training Program[No.202110412011] and “Double first-class” discipline (Chinese medicine) construction funding project in Jiangxi Province, special research on basic theories of Chinese medicine [No: JXSYLXK-ZHYI054]