Diagnostic value of miR-101 levels in blood and urine of patients with hypertensive disorder complicating pregnancy

ABSTRACT

Objectives

This study explored the miR-101 clinical significance in hypertensive disorder complicating pregnancy (HDCP).

Methods

Pregnant women with gestational hypertension (GH)/mild preeclampsia (mPE)/severe preeclampsia (sPE) were included. The miR-101 levels were measured. Correlation between miR-101 and soluble fmslike tyrosine kinase-1 (sFlt-1), miR-101 predictive value, and factors influencing HDCP grade were evaluated.

Results

Serum miR-101 was down-regulated and negatively correlated with sFlt-1. miR-101 was an independent risk factor for HDCP and decreased with HDCP severity. The area under the curve of miR-101 in differentiating GH from mPE and mPE from sPE was 0.7764 and 0.8529.

Conclusion

Serum miR-101 level may be a biomarker for grading HDCP.

KEYWORDS:

• miR-101
• gestational hypertension
• mild preeclampsia
• severe preeclampsia
• sFlt-1
• receiver operating characteristic curve
• severity of illness
• biomarkers

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethics approval

This study was approved by Academic Ethics Committee of Jincheng People’s Hospital (Approval number: JCP.No20200120001). All study subjects were informed of the study purpose and signed informed consent. All methods were carried out in accordance with relevant guidelines and regulations.

Availability of data and materials

All the data generated or analyzed during this study are included in this published article.

Authors’ contributions

YL contributed to the study concepts and study design, YW contributed to the guarantor of integrity of the entire study; YW contributed to the literature research; YL contributed to the experimental studies and data acquisition; YL, YW contributed to the manuscript preparation and JS contributed to the manuscript editing and review. All authors read and approved the final manuscript.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.