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ABSTRACT
Recurrent eczematous lesions and acute itching describe chronic actinic dermatitis (CAD). Continuous use of corticosteroids might result in a dermal adverse effect. Chitosan (CS)-coated PLGA nanoparticles encapsulated prednisolone (PDS) and co-encapsulated to poloxamer hydrogel to enhance anti-inflammatory action and reduce side effects. The PDS@NPs were synthesized using the solvent-emulsification evaporation method, and their physical and chemical properties were analysed. Ex vivo drug absorption experiment was conducted utilizing the Franz diffusion cells in vitro. Toxic effects on human fibroblasts and keratinocytes were not observed in the nanoparticle formulations. Nanoparticles and hydrogels altered PDS’s release kinetics, but not by the non-encapsulated PDS (NE@PDS). Nanoparticles could not penetrate the stratum corneum of removed the skin, which shows the nano-encapsulation of PDS improved skin absorptions. Pseudoplastic and non-Newtonian behaviour was seen in all hydrogels. The nanoformulations appear to be a promising option for glucocorticoid delivery to individuals with chronic actinic dermatitis (CAD).
Disclosure statement
No potential conflict of interest was reported by the authors.
Authors’ contributions
Quan Chen, Huiyan Deng, Bihua Liang, Runxiang Li, Huaping Li, Yanan Ke supported synthesis, characterization, molecular and biochemical analysis, data curation, formal analysis, and validation. Prof. Huilan Zhu helped with supervising the research.
Ethics approval and consent to participate
All experimental procedures were carried out according to the protocol and international standards of care for animals to adhere to the requirements established by the ethical committee of the Guangzhou Institute of Dermatology; Institute of Dermatology, Guangzhou Medical University, Guangzhou -510,095, Guangdong, China (W-22-10254A1).
Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on request.
Data availability statement
All data generated or analysed during this study are included in this submitted article. The raw data shall be made available upon request to the corresponding author.