MRP1-Transfected Cells do not Show Increased Resistance Against Oxidative Stress

Aneta Balcerczyk Department of Molecular Biophysics, University of Łódz´, 90-237 Łódz´, Poland

Błaz˙ej Rychlik Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, 03-195 Warszawa, Poland

Marcin Kruszewski Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK

Brian Burchell Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland

Grzegorz Bartosz Department of Molecular Biophysics, University of Łódz´, 90-237 Łódz´, Poland

Abstract

Sensitivity of V79 Chinese hamster cells and V79 cells transfected with human MRP1 gene to several agents inducing oxidative stress was compared. Cells overexpressing MRP1 did not show increased resistance to tert -butyl hydroperoxide, diamide, paraquat, menadione, dichromate and carmustine as estimated by cell survival and DNA damage assessed by comet assay. These findings suggest that overexpression of MRP1 does not confer increased resistance to oxidative stress.

Keywords

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

MRP1-Transfected Cells do not Show Increased Resistance Against Oxidative Stress

Information for

Open access

Opportunities

Help and information

MRP1-Transfected Cells do not Show Increased Resistance Against Oxidative Stress

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature