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Abstract
Legume intake could specifically protect against lipid peroxidation in addition to the effects associated to weight loss when included in hypocaloric diets. Thus, 30 obese subjects (age: 36 ± 8 years and BMI: 32.0 ± 5.3 kg/m2) were nutritionally treated by a 8-week energy restriction ( − 30% energy expenditure) with a legume enriched diet (4 days/week servings, ) or without legumes (control diet (CD),
). Body weight, circulating cholesterol, oxidized LDL (ox-LDL), malondialdehyde (MDA) and urinary 8-isoprostane F2α (8-iso-PGF2α) were measured at baseline and at endpoint. After the nutritional intervention, all obese subjects lost weight, specially those individuals who followed the legumes-enriched diet as compared to the CD ( − 7.7 ± 3 vs. − 5.3 ± 2.7%; p = 0.023), which was accompanied by marked decreases in total cholesterol levels (p < 0.001) and statistically significant diet-related reductions on plasma ox-LDL, plasma MDA and urinary 8-iso-PGF2α output.
Therefore, a balanced diet with moderate caloric restriction including 4 day/week legume servings empowered the oxidative stress improvement related to weight loss through a reduction in lipid peroxidation as compared to a control hypocaloric diet.
| Abbreviations | ||
| TAC | = | total antioxidant capacity |
| MDA | = | malondialdehyde |
| ox-LDL | = | oxidized LDL |
| 8-iso-PGF2α | = | 8-isoprostane F2α |
| AOP | = | total plasma antioxidant power |
| Abbreviations | ||
| TAC | = | total antioxidant capacity |
| MDA | = | malondialdehyde |
| ox-LDL | = | oxidized LDL |
| 8-iso-PGF2α | = | 8-isoprostane F2α |
| AOP | = | total plasma antioxidant power |