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Abstract
Renal and cardiac benefits of renin-angiotensin system inhibition exceed blood pressure (BP) reduction and seem to involve mitochondrial function. It has been shown that RAS inhibition prevented mitochondrial dysfunction in spontaneously hypertensive rats (SHR) kidneys. Here, it is investigated whether a non-antihypertensive enalapril dose protects cardiac tissue and mitochondria function. Three-month-old SHR received water containing enalapril (10 mg/kg/day, SHR+Enal) or no additions (SHR-C) for 5 months. Wistar-Kyoto rats (WKY) were normotensive controls. At month 5, BP was similar in SHR+Enal and SHR-C. In SHR+Enal and WKY, heart weight and myocardial fibrosis were lower than in SHR-C. Matrix metalloprotease-2 activity was lower in SHR+Enal with respect to SHR-C and WKY. In SHR+Enal and WKY, NADH/cytochrome c oxidoreductase activity, eNOS protein and activity and mtNOS activity were higher and Mn-SOD activity was lower than in SHR-C. In summary, enalapril at a non-antihypertensive dose prevented cardiac hypertrophy and modifies parameters of cardiac mitochondrial dysfunction in SHR.
| Abbreviations | ||
| ACE | = | angiotensin converting enzyme |
| ANG-II | = | angiotensin II |
| BP | = | blood pressure |
| ECM | = | extracellular matrix |
| eNOS | = | endothelial nitric oxide synthase |
| MMP | = | matrix metalloprotease |
| Mn-SOD | = | manganese superoxide dismutase |
| mtMP | = | mitochondrial membrane potential |
| mtNOS | = | mitochondrial nitric oxide synthase |
| RAS | = | renin-angiotensin system |
| ROS | = | reactive oxygen species |
| SHR | = | spontaneously hypertensive rats |
| WKY | = | Wistar-Kyoto rats |
| Abbreviations | ||
| ACE | = | angiotensin converting enzyme |
| ANG-II | = | angiotensin II |
| BP | = | blood pressure |
| ECM | = | extracellular matrix |
| eNOS | = | endothelial nitric oxide synthase |
| MMP | = | matrix metalloprotease |
| Mn-SOD | = | manganese superoxide dismutase |
| mtMP | = | mitochondrial membrane potential |
| mtNOS | = | mitochondrial nitric oxide synthase |
| RAS | = | renin-angiotensin system |
| ROS | = | reactive oxygen species |
| SHR | = | spontaneously hypertensive rats |
| WKY | = | Wistar-Kyoto rats |