Assessment of antioxidant and antiparkinsonian potential of a new diterpene isolated from Croton argyrophylloides

Abstract

Oxidative stress is related to health problems including neurological and neurodegenerativedisturbs, such as Parkinson’s disease. Natural compounds are reported as source of antioxidant molecules. Therefore, this study aimed to analyze the antioxidant and neuroprotective potential of a new diterpene isolated from C. argyrophylloides (MP-1). Male Wistar rats (250–300 g) were used to evaluate MP-1 antiparkinsonian potential through neurodegenerative model induced by the neurotoxin 6-hydroxydopamine (21 μg). On the 14th day, animals were submitted to behavioral tests and on the 15th day, brain areas were dissected to neurochemical analyzes. MP-1 demonstrated a high antioxidant capacity in vitro and decreased the parkinsonian effects, such as behavioral changes, motor alterations, and body weight loss. MP-1 was also able to control the upregulated levels of nitrosative stress and lipid peroxidation. These findings suggest MP-1 as a diterpene with high antioxidant capacity which might be used to development of new approach against Parkinson’s disease.

Graphical Abstract

Keywords:

• Diterpenes
• neuroprotection
• Parkinson’s disease

Acknowledgements

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Ministério da Ciência, Tecnologia e Inovações (MCTI), Núcleo de Biotecnologia de Sobral (NUBIS) and Faculdade de Medicina de Sobral (FAMED).

Disclosure statement

The authors declare that there were no conflicts of interest that could have jeopardized the performance and impartiality of this scientific study.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.