Recent progress in nanotechnology-based drug carriers for resveratrol delivery

Abstract

Resveratrol is a polyphenol with diverse pharmacological activities, but its clinical efficacy is limited due to low solubility/permeability, light-induced isomerization, auto-oxidation, and rapid metabolism. Nanodelivery systems, such as liposomes, polymeric nanoparticles, lipid nanocarriers, micelles, nanocrystals, inorganic nanoparticles, nanoemulsions, protein-based nanoparticles, exosomes, macrophages, and red blood cells (RBCs) have shown great potential for improving the solubility, biocompatibility, and therapeutic efficacy of resveratrol. This review comprehensively summarizes the recent advances in resveratrol nanoencapsulation and describes potential strategies to improve the pharmacokinetics of existing nanoformulations, enhance targeting, reduce toxicity, and increase drug release and encapsulation efficiency. The article also suggests that in order to avoid potential safety issues, resveratrol nanoformulations must be tested in vivo in a wide range of diseases.

Keywords:

• Resveratrol
• nanocarriers
• nanoencapsulation
• drug delivery system
• bioavailability

Ethical approval statement

NA.

Author contributions

Chunhong Li and Zhen Wang contributed equally. All authors have given approval to the final version of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors

Additional information

Funding

This work was supported by the [Science and Technology Department of Sichuan Province #1] under Grant [number 23NSFSC0589]; [Xuzhou District People’s Government - Science and Technology Project of Southwest Medical University #2] under grant [number 2019-YBXNYD-4]; and [Scientific and technological achievements Transformation Project of Southwest Medical University #3] under Grant [number 2020-6].