Research progress of ophthalmic preparations of immunosuppressants

Abstract

Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants are drugs that can inhibit the body’s immune response. Considering drug side effects such as hepatorenal toxicity and the unique structure of the eye, incorporating immunosuppressants into ophthalmic nanodrug delivery systems, such as microparticles, nanoparticles, liposomes, micelles, implants, and in situ gels, has the advantages of improving solubility, increasing bioavailability, high eye-target specificity, and reducing side effects. This study reviews recent research and applications of this aspect to provide a reference for the development of an ophthalmic drug delivery system.

Keywords:

• Immunosuppressant
• ophthalmic
• nano-delivery system
• immune eye disease

Acknowledgement

We thank Home for Researchers editorial team (www.home-for-researchers.com) for language editing service.

Disclosure statement

The authors declare no conflict of interest.

Ethical approval statement

NA.

Additional information

Funding

This project is supported by Basic Public Welfare Research Project of Zhejiang Province (No. GF22H128127), National Natural Science Youth Foundation of China (No. 82000864), Science and Technology Projects of Medicine and Health of Zhejiang (No. 2021KY648), The special project of Hangzhou Medical College (No. YS2022009), Science and Technology Project of Jinhua (No. 2021-4-305) and Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province (2019E10021).