An update on the advances in the field of nanostructured drug delivery systems for a variety of orthopedic applications

Abstract

Nanotechnology has made significant progress in various fields, including medicine, in recent times. The application of nanotechnology in drug delivery has sparked a lot of research interest, especially due to its potential to revolutionize the field. Researchers have been working on developing nanomaterials with distinctive characteristics that can be utilized in the improvement of drug delivery systems (DDS) for the local, targeted, and sustained release of drugs. This approach has shown great potential in managing diseases more effectively with reduced toxicity. In the medical field of orthopedics, the use of nanotechnology is also being explored, and there is extensive research being conducted to determine its potential benefits in treatment, diagnostics, and research. Specifically, nanophase drug delivery is a promising technique that has demonstrated the capability of delivering medications on a nanoscale for various orthopedic applications. In this article, we will explore current advancements in the area of nanostructured DDS for orthopedic use.

Keywords:

• Nanotechnology
• drug delivery system
• orthopedic
• bone
• tumor

Authors’ contributions

All writers contributed to the study by fulfilling the criteria approved by ICMJE. Acquisition of data: SJ, CZ, LF, HZ, XH, WL, and JZ. Analysis and interpretation of data: SJ, CZ, LF, HL, WM, WL, and JZ. Manuscript drafting: SJ, HL, WM, WL, and JZ. Critical revision: SJ, CZ, LF, HZ, XH, HL, WM, WL, and JZ. Study conception and design: SJ, CZ, LF, HZ, XH, HL, WM, WL, and JZ. Financial support: SJ, CZ, LF, HZ, XH, HL, WM, WL, and JZ. The submitted version of the work was studied and accepted by all writers. All writers have agreed to be personally responsible for their contributions as well as to make sure any questions about the reliability or precision of any part of the work, even if the writer was not involved personally, are properly investigated and resolved, and that the resolution is reported in the literature.

Disclosure statement

No potential conflict of interest was reported by the authors.

Data availability statement

On reasonable request, all data can be obtained from the respective author.

Additional information

Funding

This research was funded by Public Technology Applied Research Projects of Zhejiang Province (LGF22H060023 to WQL), Medical and Health Research Project of Zhejiang Province (2023KY1303 to HGL, 2021KY1164 to LFF), Traditional Chinese Medicine Science and Technology Projects of Zhejiang Province (2022ZB380 to JYZ, 2023ZL765 to WYM), Science and Technology Project of Zhoushan (2022C31034 to CZ, 2022C31022 to XGH, 2023C31019 to HJZ).