Kartogenin delivery systems for biomedical therapeutics and regenerative medicine

Abstract

Kartogenin, a small and heterocyclic molecule, has emerged as a promising therapeutic agent for incorporation into biomaterials, owing to its unique physicochemical and biological properties. It holds potential for the regeneration of cartilage-related tissues in various common conditions and injuries. Achieving sustained release of kartogenin through appropriate formulation and efficient delivery systems is crucial for modulating cell behavior and tissue function. This review provides an overview of cutting-edge kartogenin-functionalized biomaterials, with a primarily focus on their design, structure, functions, and applications in regenerative medicine. Initially, we discuss the physicochemical properties and biological functions of kartogenin, summarizing the underlying molecular mechanisms. Subsequently, we delve into recent advancements in nanoscale and macroscopic materials for the carriage and delivery of kartogenin. Lastly, we address the opportunities and challenges presented by current biomaterial developments and explore the prospects for their application in tissue regeneration. We aim to enhance the generation of insightful ideas for the development of kartogenin delivery materials in the field of biomedical therapeutics and regenerative medicine by providing a comprehensive understanding of common preparation methods.

Keywords:

• Kartogenin
• biomaterials
• delivery system
• controlled release
• tissue engineering

Author contributions

P. Chen: Writing - Original Draft, Project administration. X. Liao: Writing - review & editing.

Disclosure statement

No potential conflict of interest was reported by the authors.

Data availability statement

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

Additional information

Funding

This work was supported in part by grants from the National Natural Science Foundation of China [12202089], the Research Foundation of Chongqing University of Science and Technology [ckrc2021020], the Innovation-entrepreneurship Seed Foundation of Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology [1155108202108], and Chongqing Talents Project [CQYC20210302379].