Advances in smart delivery of magnetic field-targeted drugs in cardiovascular diseases

Abstract

Magnetic Drug Targeting (MDT) is of particular interest to researchers because of its good loading efficiency, targeting accuracy, and versatile use in vivo. Cardiovascular Disease (CVD) is a global chronic disease with a high mortality rate, and the development of more precise and effective treatments is imminent. A growing number of studies have begun to explore the feasibility of MDT in CVD, but an up-to-date systematic summary is still lacking. This review discusses the current research status of MDT from guiding magnetic fields, magnetic nanocarriers, delivery channels, drug release control, and safety assessment. The current application status of MDT in CVD is also critically introduced. On this basis, new insights into the existing problems and future optimization directions of MDT are further highlighted.

GRAPHICAL ABSTRACT (BY FIGDRAW.)

Keywords:

• Magnetic field targeting
• magnetic nanocarriers
• drug release control
• cardiovascular disease

Acknowledgments

The authors would like to acknowledge the convenience of Figdraw (https://www.figdraw.com/) for diagramming.

Ethical approval

Not applicable.

Authors’ contributions

XW was responsible for the conception, charting, and first draft of this paper. RB was responsible for the conception, critical revision, and final approval of this paper. All authors agree to be accountable for all aspects of the work.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

Additional information

Funding

This work was supported by grants from the Jiangxi Provincial Department of Education Science and Technology Research Project [GJJ2200176].