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Abstract
Cisplatin-induced enhancement of lipofection was tested for the involvement of cell death via reactive oxygen species (ROS).A direct injection of exogenous ROS into tumor-bearing mice significantly sensitized tumor cells for in situ lipofection. Chemotherapeutic drugs, independent of ROS production, also significantly facilitated transduction, which was maximum at nontoxic or subtoxic doses and was host independent. Transplatin and pro-oxidants, having no antitumor activity, significantly facilitated transduction, while antioxidants had little effect. These results suggest that cisplatinfacilitated lipofection in tumor cells may be a general phenomenon of toxic chemicals inducing cell death in a mammalian system.