Rheological and physical parameters correlations in formulations with pinhão derivatives stability study: building up an analytical route

Abstract

This study focuses on the correlation investigation between rheological and physical parameters and how it can contribute to optimize the topical formulations development. A gel and an emulgel containing pinhão derivatives, and their respective controls, were analyzed along six months of storage. A flowchart of analyses was proposed to use in topical formulation development when a benchmark is the goal or when it is necessary to change some raw material. All formulations were stable over the storage time and the formulations containing pinhão starch and coat extract presented similar properties to those of the control formulations. Correlations between rheological and physical data, as moisture content and particle size, were determined using Pearson’s correlation coefficient. A moderate positive correlation was verified between particle size distribution and flow index, and a strong positive correlation between particle size and flow index. It was also found that the higher the moisture content, the higher the consistency index, quality factor, and apparent viscosity. The correlation analyses applied in this study contributed to build up an analytical route for topical formulation development, saving time and costs.

Keywords:

• Correlation
• topical formulations development
• pinhão applications
• rheology
• microscopy
• stability

Acknowledgements

The authors would like to thank the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) from Brazil for providing financial support.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors would like to thank the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) [grant number: 1090721] from Brazil for providing financial support.