Biodegradable Microparticles Based on Poly(D,L-Lactide) as a Protective Transport System in Ruminant Digestion

Abstract

Despite its abundance in their diet, cattle are unable to directly digest cellulose. The bovine digestive tract overcomes this problem via the rumen, a portion of the stomach containing mixed anaerobic bacteria. These microbes, while breaking down foodstuffs, also perform undesirable processes such as biohydrogenation, in which unsaturated fatty acids become saturated, with deleterious cardiovascular effects. An approach to preventing this saturation entailing the use of polymeric microspheres to encapsulate feed supplements is proposed, with a single emulsion, solvent evaporation method used to formulate poly(D,L-lactide) microparticles for delivery of unsaturated fatty acids to ruminant abomasum.

Keywords:

• lipid encapsulation
• poly(D,L-lactide)
• PDL
• polymeric microspheres
• poly(lactide-co-caprolactone)
• ruminant nutrition