Research Strategy for Assessing Human Risk From Inhaled Nasal Toxicants

Abstract

Information exists on the nasal toxicity in humans of only a few xenobiotic compounds. Thus, as for many other materials, it is necessary to conduct studies in laboratory animal species and extrapolate the findings to people. This article advocates a strategy for conducting such research that emphasizes the need for obtaining a mechanistic and quantitative understanding of the linkages between exposure and dose to critical biological targets and adverse responses. Central to the strategy is the conduct and integration of data obtained from physical and chemical characterization of potential toxicants, in vitro studies with cells and tissues from humans and laboratory animals, in vivo studies in laboratory animals, and human data when they exist.