ABSTRACT
Background
Epinephrine in liposuction solution mediated vasoconstriction thus decrease in adrenergic side effects, local anesthetic toxicity, and bleeding. The optimum safe adrenaline concentration was not well investigated.
Aim
This study aimed to compare between adrenaline 1 mg/L and 2 mg/L in tumescent fluid concerning hemodynamics during abdominal liposuction operations.
Methods
Forty cases scheduled for liposuction for abdomen and flanks and body were involved in this randomized, triple-blind, controlled trial. Cases were randomized equally into two groups. Group A (low adrenaline concentration group): received 1 mg per liter of epinephrine. Group B (high adrenaline concentration group): received 2 mg per liter of epinephrine.
Results
Intraoperative heart rate and mean arterial blood pressure at base line were insignificantly different between both groups (p value > 0.05) while at 30, 60, 90, and end of surgery were significantly higher in group B group as opposed to group A (p value < 0.05). Incidence of sinus tachycardia and PVCs were significantly higher in group B than group A (P < 0.05), while surgeon satisfaction was comparable between both groups (p value > 0.05).
Conclusions
In liposuction procedures, the safest adrenaline concentration is 1 mg/L as evidenced by hemodynamics stability and surgeon satisfaction thus even in high volume liposuction, the adrenaline concentration should not exceed 1 mg/L and should be handled to cover the used crystalloid solution.
Competing interests
The authors have no relevant financial or non-financial interests to disclose.
Author contributions
All authors participated in preparing this clinical trial and approved of the work as it is being submitted. All authors read and approved the final manuscript.
Availability of data and materials
The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
Ethics approval and consent to participate
This study was performed in line with the principles of the Declaration of Helsinki. Each patient provided written informed consent. The research was performed after the approval of the Ethical Committee Benha university Hospitals (approval code: RC.3.1.2023), registration of clinicaltrials.gov (ID: NCT05822765) and the date of first registration was (21/04/2023).
Disclosure statement
No potential conflict of interest was reported by the author(s).