Immunoglobulin D lambda multiple myeloma and amyloidosis with predominant soft tissue involvement

Abstract

Multiple myeloma (MM) is associated with amyloidosis in approximately 15% of the patients. The most frequent presenting signs of such an association are nephrotic syndrome, cardiomyopathy and peripheral neuropathy. Amyloid arthropathy is not a frequent feature. We report a patient with immunoglobulin D (IgD) lambda type MM with presenting symptoms related to mucocutaneous amyloidosis and also amyloid arthropathy. He had no clinical and laboratory involvement due to nephrotic syndrome or cardiomyopathy. IgD myeloma is a rare form of MM and therefore much of the information about the disease is derived from case reports describing patients with associated symptoms. Our case also shows an unusual organ distribution of amyloid.

Keywords:

• IgD lambda myeloma
• AL amyloidosis
• amyloid arthropathy
• mucocutaneous amyloidosis

Abbreviations
MM	=	multiple myeloma
IgD	=	immunoglobulin D

Abbreviations
MM	=	multiple myeloma
IgD	=	immunoglobulin D