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ABSTRACT
To study a case of a middle-aged male with a non-tumor-associated Epstein–Barr virus (EBV) infection associated with Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE), to explore the role of EBV in the pathogenesis of anti-NMDARE. The patient was diagnosed with “Anti-NMDARE, EBV infection” by using Cerebrospinal fluid (CSF) autoimmune encephalitis profile, and Metagenomics Next-Generation Sequencing (mNGS) pathogenic microbial assays, we discuss the relationship between EBV and NMDARE by reviewed literature. EBV infection may trigger and enhance anti-NMDARE, and the higher the titer of NMDAR antibody, the more severe the clinical presentation.
Acknowledgements
We thank the patient for their support in our study.
Abbreviations
| Ab | = | antibody |
| BBB | = | blood-brain barrier |
| CA | = | capsid antigen |
| CBA | = | Cell Based Assay |
| CMV | = | Cytomegalovirus |
| CNS | = | central nervous system |
| CSF | = | cerebrospinal fluid |
| dsDNA | = | double-stranded DNA |
| EA | = | early antigen |
| EBV | = | Epstein-Barr virus |
| EEG | = | electroencephalogram |
| IIF | = | Indirect Immunofluorescence assay |
| HSV | = | Herpes simplex virus |
| IVIG | = | intravenous immunoglobulin |
| MRI | = | Magnetic Resonance Imaging |
| MRA | = | magnetic resonance angiography |
| mNGS | = | Metagenomics Next-Generation Sequencing |
| NA | = | nuclear-antigen |
| NMDARE | = | N-methyl-D-aspartate receptor encephalitis |
| NR1 | = | N-methyl-D-aspartate receptor subunit 1 |
| OB | = | oligoclonal band |
| PCR | = | polymerase chain reaction |
| TBA | = | Tissue Based Assay |
| RV | = | Rubella virus |
| TBA | = | tissue based assay |
| TOX | = | Toxoplasma. |
Disclosure statement
No potential conflict of interest was reported by the author(s).