Evaluation of the Potential Cytotoxicity of Dental Bleaching Agents

Sérgio L. Zouain–Ferreira Universidade Federal do Rio de Janeiro, Rio de Janeiro;; Faculdade de Odontologia, Universidade Federal de Juiz de Fora, Juiz de Fora;

Thalyta R. F. Zouain–Ferreira Fundacao Oswaldo Aranha, Faculdade de Odontologia, Volta Redonda;

Kátia R. H. Cervantes Dias Faculdade de Odontologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ 20551–030;

Adriano Caldeira-De-Araújo Departamento de Biofo sica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro 87, Rio de Janeiro, RJ 20551–030;

Mario Bernardo–Filho Departamento de Biofo sica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro 87, Rio de Janeiro, RJ 20551–030;; 6Instituto Nacional do Cancer, Coordenadoria de Pesquisa, Praca Cruz Vermelha 23, Rio de Janeiro, RJ 20230–130, Brazil

Abstract

We studied the effects of dental bleaching agents (Insta-Brite ™ , Karisma ™ , Opalescence ™ and Whiteness ™ ) on the lysogenic induction and survival of Escherichia coli strains with different abilities to repair DNA damage. To evaluate lysogenic induction, an E. coli GY5027 ( &#117 ) culture was incubated with solutions of bleaching agents. Cultures of E. coli AB1157 ( wild type ), AB2463 ( recA ) and BW9091 ( xthA ) were incubated with the bleaching agents and the survival fractions determined. The bleaching agents were found to promote lysogenic induction and to decrease the survival of the bacterial strains. These results suggest that bleaching agents are capable of inducing DNA damage in oral bacteria.

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Evaluation of the Potential Cytotoxicity of Dental Bleaching Agents

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Evaluation of the Potential Cytotoxicity of Dental Bleaching Agents

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