Abstract
This paper celebrates the centenary of the publication of a milestone paper written by geologist T. C. Chamberlin and highlights how the intellectual process of the method of multiple working hypotheses is a more effective and less problematic way of arriving at the truth of a given situation. This approach has as much relevance today as it did a hundred years ago. It is proposed that the current pharmacodox paradigm might, in fact, be an example of the less intellectually developed 'method of the ruling theory'.