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Abstract
The objective of this study was to evaluate the efficacy and safety of the vaginal self-administration of 600 μg misoprostol up to a maximum administration of three doses in a 24-h period, one every 8 h, for abortion up to 9 weeks' gestation. A group of 90 voluntary women with gestations from 35 to 63 days participated in the study. All women who aborted received a single additional dose of 600 μg misoprostol. Outcome measures included successful abortion (complete abortion without requiring surgical procedure) and side-effects. Complete abortion occurred in 57/89 (64%, 95% confidence interval 53–74%) subjects. The mean expulsion time was 7.4 ± 3.8 h (median 7.2 h, range 3–20 h) for all women who aborted within the first 24 h of the administration of misoprostol. Thirty-two cases failed to abort, 28 cases due to failure of the method, of which 24 had a negative cardiac rhythm after the third dose, and four cases due to the doctor's decision.
The results obtained in this study led us to the conclusion that the 600μg misoprostol dose regimen was not adequate to produce a high or an acceptable abortive efficacy.
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