https://orcid.org/0000-0001-8693-9964
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Abstract
Objectives
Progestins used in contraception are either components of combined hormonal contraceptives or are used as a single active ingredient. Progestins are highly effective in long-term contraception and have a very good safety profile with very few contraindications.
Methods
An oestrogen-free ovulation inhibitor POP has been authorised in the USA and the EU. It contains 4 mg of drospirenone (DRSP). The hormone administration regimen of 24 days followed by a 4-day hormone-free period was chosen to improve bleeding control and to maintain oestradiol concentrations at early follicular- phase levels, preventing oestrogen deficiency.
Results
Clinical trials have demonstrated high contraceptive effectiveness, a very low risk of cardiovascular risk events and a favourable bleeding pattern. Due to the long half-life of DRSP (30–34 h), the effectiveness is maintained even in case of a forgotten pill on a single occasion. Studies involving deliberate 4 days in one cycle 24-hour delays in taking a pill have demonstrated that ovulation inhibition is maintained if a single pill is missed.
Conclusions
This review article will describe the clinical impact in the daily use of the 4 mg DRSP only pill and the resulting data on the effectiveness and safety of this hormonal contraceptive.
SHORT CONDENSATION
The 4 mg drospirenone-only pill improves the bleeding profile in comparison to 0.075 mg desogestrel and achieves high contraceptive efficacy even with a 24 h missed pill window.
摘要
目的：用于避孕的孕激素要么是联合激素避孕药的组成部分, 要么是作为单一活性成分应用。孕激素在长期避孕中非常有效, 并且具有非常好的安全性, 几乎没有禁忌证。
方法：一种不含雌激素的排卵抑制剂, POP已在美国和欧盟获得授权。它含有4 mg的屈螺酮（DRSP）。选择24天的激素给药方案, 然后是4天的无激素期, 以改善出血控制, 将雌二醇浓度维持在卵泡期早期水平, 防止雌激素缺乏。
结果：临床试验表明, 该药具有很高的避孕效果, 发生心血管风险事件的风险很低, 并且具有良好的出血模式。由于DRSP的半衰期长（30-34小时）, 即使在单次忘记服药的情况下也能保持其有效性。在一个周期内服药4天后故意推迟24小时再服药的研究表明, 如果错过一次服药, 排卵抑制作用仍可维持。
结论：这篇综述文章将描述在每天应用4 mg单纯DRSP片的临床影响, 以及由此产生的关于这种激素避孕药的有效性和安全性的数据。
Disclosure statement
Pedro Antomio egidor and Enrico Colli are employes of Exeltis which markets The DRSP-only pill. The other authors have participated in educational activities sponsored by Exeltis.
Correction Statement
This article was originally published with errors, which have now been corrected in the online version. Please see Correction (http://dx.doi.org/10.1080/13625187.2023.2187161)