CYP17 polymorphism and hot flushes in postmenopausal women

Abstract

Objective To investigate the association between the CYP17α gene polymorphism and hot flushes in postmenopausal women.

Methods Ninety-three non-hysterectomized, postmenopausal women were enrolled in this study. Vasomotor symptoms were assessed at the baseline visit and based on information provided by each participant. The genotypic polymorphism of CYP17α gene was analyzed by PCR-RFLP assay using genomic DNA isolated from peripheral blood lymphocytes.

Results Thirty-six women reported hot flushes of mild intensity, 25 reported hot flushes of moderate intensity and 32 of severe intensity. There was no significant difference between the severity of hot flushes and the CYP17 genotype or allele frequencies, 0.58 and 0.67 respectively. No association was found between hot flush severity and the CYP17 allele (odds ratio = 1.17, p = 0.61).

Conclusion The results of this study suggest that the CYP17 MspAI polymorphism was not significantly associated with an increased risk of reporting hot flushes.

At the World Congress on Menopause in Madrid, May 2008, Dr Massad-Costa was awarded the Robert Greenblatt Prize for Basic Science for the study reported in this paper.

Key words:

• POSTMENOPAUSE
• HOT FLUSH
• CYP17α
• POLYMORPHISM