Ghrelin and orotic acid increased in subclinical mastitis

F. Karatas Department of Chemistry, Faculty of Arts and Sciences, University of Firat, 23119, Elazig, Turkey

Dr S. Aydin Department of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Firat Medical Center, Elazig, Turkey

E. Kaygusuzoglu Department of Obstetrics and Gynecology, Faculty of Veterinary, University of Firat, 23119, Elazig, Turkey

H. Yildiz Department of Obstetrics and Gynecology, Faculty of Veterinary, University of Firat, 23119, Elazig, Turkey

F. A. Erulas Department of Chemistry, Faculty of Arts and Sciences, University of Firat, 23119, Elazig, Turkey

Y. Ozkan Department of Endocrinology, Internal Medicine, School of Medicine, Firat University, Firat Medical Center, Elazig, Turkey

Abstract

Hormone ghrelin and orotic acid accelerate wound healing as well as controlling inflammation and immunity. We have, therefore, investigated the serum and milk levels of ghrelin and orotic acid in dairy cows with (n = 21) or without (n = 21) subclinical mastitis. Acylated and des-acylated ghrelin as well as orotic acid concentration were detected by using high performance liquid chromatography (HPLC). The results revealed that ghrelin level in milk and serum was significantly higher in dairy cows with subclinical mastitis than that of dairy cows without subclinical mastitis. This was also the case when the orotic acid concentrations in dairy cows with subclinical mastitis were compared with those dairy cows without subclinical mastitis. In conclusion, ghrelin and orotic acid occur in particularly high concentrations in subclinical mastitis, and might, therefore, be required in greater amounts for tissue repair and may be also used as a indicator for subclinical mastitis.

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Ghrelin and orotic acid increased in subclinical mastitis

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Ghrelin and orotic acid increased in subclinical mastitis

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