![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
The effects of high-fat-associated kidney damage in humans are not completely elucidated. Animal experiments are essential to understanding the mechanisms underlying human diseases. This systematic review aimed to compile evidence of the role of a high-fat diet during the development of renal lipotoxicity and fibrosis of Wistar rats to understand whether this is a satisfactory model for the study of high fat-induced kidney damage. We conducted systematic searches in PUBMED, EMBASE, Lilacs, and Web of Science databases from inception until May 2021. The risk of bias was assessed using SYRCLE toll. Two reviewers independently screened abstracts and reviewed full-text articles. A total of 11 studies were included. The damage varied depending on the age and sex of the animals, time of protocol, and amount of fat in the diet. In conclusion, the Wistar rat is an adequate animal model to assess the effects of a high-fat diet on the kidneys.
A high-fat diet may promote kidney damage in Wistar rats.
Wistar rat is efficient as an animal model to study high-fat-induced kidney damage.
The effect of the diet depends on the fat amount, consumption time, and animal age.
Highlights
Author contributions
ROP and LAC participated in formulating the research question, data analysis, interpreting the findings, and writing the article. DF participated in formulating the research question, designing the study, supervising the project, and writing the article. GK participated in the interpretation of findings, writing of the article, and text review. VF and PF participated in the design of the study, supervising the project, and writing the article.
Disclosure statement
No potential conflict of interest was reported by the authors.
Data availability statement
The authors confirm that the data supporting the findings of this study are available within the article and its supplementary materials.