Long non-coding RNAs as emerging regulators of miRNAs and epigenetics in diabetes-related chronic kidney disease

Abstract

Diabetes is one of the major cause of chronic kidney disease (CKD), including “diabetic nephropathy,” and is an increasingly prevalent accelerator of the progression of non-diabetic forms of CKD. The long non-coding RNAs (lncRNAs) have come into the limelight in the past few years as one of the emerging weapons against CKD in diabetes. Available data over the past few years demonstrate the interaction of lncRNAs with miRNAs and epigenetic machinery. Interestingly, the evolving data suggest that lncRNAs play a vital role in diabetes-associated CKD by regulation of epigenetic enzymes such as DNA methyltransferase, histone deacetylases, and histone methyltransferases. LncRNAs are also engaged in the regulation of several miRNAs in diabetic nephropathy. Hence this review will elaborate on the association between lncRNAs and their interaction with epigenetic regulators involved in different aspects and thus the progression of CKD in diabetes.

Keywords:

• LncRNAs
• miRNAs
• epigenetics
• histone modifications
• chronic kidney disease

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

No raw data is associated with the study since this is a review article.

Additional information

Funding

HJA was supported by the Deutsche Forschungsgemeinschaft (AN372/24-1). ABG sincerely acknowledges the financial support provided by Birla Institute of Technology and Science-Pilani, Pilani, for carrying out this work.