Antifungal Flavonoids from Ballota glandulosissima

Abstract

The flavonoids kumatakenin (1), pachypodol (2), 5-hydroxy-7,3′,4′-trimethoxyflavone (3), velutin (4), salvigenin (5), retusin (6) and corymbosin (7) have been isolated from the aerial parts of Ballota glandulosissima Hub.-Mor & Patzak. Among them, 2–4 and 7 have not been reported previously in the genus Ballota. The antibacterial and antifungal activities of 1–4 and 6 were tested against Bacillus subtilis, Staphylococcus aureus, Staphylococcus faecalis, Echerichia coli, Pseudomonas aeruginosa, Candida albicans, Candida krusei and Candida galabrata.

Keywords: :

• Antifungal activity
• Ballota glandulosissima Hub.-Mor & Patzak
• Lamiaceae
• kumatakenin
• pachypodol
• 5-hydroxy-7,3′,4′-trimethoxyflavone
• velutin
• salvigenin
• retusin
• corymbosin