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Abstract
The present study evaluated the hypoglycemic activity in the ethanol extract of Eugenia jambolana (EJ) seeds and its kernel. Administration of the extracts at the dosage of 100 mg/kg body weight/day for 30 days resulted in a marked decrease in the levels of blood glucose, urea and urine sugar in streptozotocin (STZ) (55 mg/kg body weight) induced diabetes in rats. The hypoglycemic efficacy was compared with glibenclamide. The activities of carbohydrate metabolizing enzymes were brought back to near normal level after the treatment and glucose homeostasis was maintained even two weeks after the cessation of treatment. The hypoglycemic activity was more pronounced in kernel extract treated diabetic rats than in whole seed and glibenclamide treated diabetic rats.