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Research Article

New Anticancer Drugs from Cultured and Collected Marine Organisms

William Fenical Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.

Paul Jensen Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.

Christopher Kauffman Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.

Stephanie Mayhead Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.

D. Faulkner Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.

Catherine Sincich Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.

M. Rao Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.

Eric Kantorowski Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.

Lyndon West Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.

Wendy Strangman Center for Marine Biotechnology, and Biomedicine Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0212, U.S.A.

Yuzuru Shimizu Departmental of Biomedical Sciences, School of Pharmacy, University of Rhode, Island, Kingston, RI, 02881, U.S.A.

Bo Li Departmental of Biomedical Sciences, School of Pharmacy, University of Rhode, Island, Kingston, RI, 02881, U.S.A.

Sudhakararao Thammana Departmental of Biomedical Sciences, School of Pharmacy, University of Rhode, Island, Kingston, RI, 02881, U.S.A.

Katherine Drainville Departmental of Biomedical Sciences, School of Pharmacy, University of Rhode, Island, Kingston, RI, 02881, U.S.A.

Michael Davies-Coleman Department of Chemistry, Rhodes University, Grahamstown, South Africa

Robert Kramer Oncology Drug Discovery Program, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, 08543-4000, U.S.A.

Craig Fairchild Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.

William Rose Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.

Robert Wild Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.

Gregory Vite Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.

Russell Peterson Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, U.S.A.

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Abstract

This paper provides an outline of a collaborative research project between researchers at the University of California, San Diego, University of Rhode Island, and the Bristol-Myers Squibb Pharmaceutical Research Institute, with participating members from the Developmental Therapeutics Branch of the National Cancer Institute. The program, formally funded by the National Cancer Institute under the National Cooperative Drug Discovery Groups (NCDDG) program, seeks to discover new anticancer drugs from marine organisms, in particular invertebrates such as sponges and ascidians, and marine microalgae, marine bacteria and fungi. In this report, the program and results obtained since its beginning in 2000 will be summarized.

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New Anticancer Drugs from Cultured and Collected Marine Organisms

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New Anticancer Drugs from Cultured and Collected Marine Organisms

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