Antihyperglycemic Activity of Cyamopsis tetragonoloba. Beans on Blood Glucose Levels in Alloxan-Induced Diabetic Rats

Abstract

The effect of administering an ethanol extract of Cyamopsis tetragonoloba. Linn. (Leguminosae) beans on blood glucose levels in normal and alloxan-induced diabetic rats was evaluated in this study. The ethanol extract of beans at 250 mg/kg body weight significantly reduced the blood glucose levels in alloxan-induced diabetic rats within 3 h of administration. Continued administration of the extract at the same dose daily for 10 days produced a statistically significant reduction in the blood glucose levels, whereas marginal activity was seen in normal and glucose-loaded rats.

Keywords:

• Alloxan-induced diabetic rats
• beans
• Cyamopsis tetragonoloba
• hypoglycemic activity
• leguminosae

Notes

^a.Values are means ±SE; n = 5, *p < 0.001, **p < 0.01, NS, no significant difference relative to the vehicle.

^a.Values are means ±SE; n = 5*p < 0.001, NS, no significant difference relative to the vehicle.

^a.Values are means ±SE; n = 5*p < 0.001, NS, no significant difference relative to the vehicle.

^a.Values are means ±SE; n = 5*p < 0.001, NS, no significant difference relative to the vehicle.