Effect of Compounds Isolated from Natural Products on IFN-γ/LPS–Induced Nitric Oxide Production in RAW 264.7 Macrophages

A. Syahida Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

D.A. Israf Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

N.H. Lajis Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

S. Khozirah Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

M. Habsah Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Jasril Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

D. Permana Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

I. Norhadiani Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

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Abstract

The current study was designed to evaluate whether compounds isolated from local medicinal plants in Malaysia suppressed nitric oxide (NO) production in inflammation. The murine monocytic macrophage (RAW 264.7) cell line was used as a target cell and activated by interferon-γ. (IFN-γ.) and lipopolysaccharide (LPS). Our current study has identified four phytochemicals, namely atrovirinone, cardamonin, flavokawin B, and zerumbone, that inhibit pathological NO generation. These compounds are candidates for further bioassay studies to determine their suitability as drug leads.

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Effect of Compounds Isolated from Natural Products on IFN-γ/LPS–Induced Nitric Oxide Production in RAW 264.7 Macrophages

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Effect of Compounds Isolated from Natural Products on IFN-γ/LPS–Induced Nitric Oxide Production in RAW 264.7 Macrophages

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