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ABSTRACT
Effects of garlic (Allium sativum. L.) extract on the temporal patterns of circulatory lipid peroxidation products and antioxidants during N.-nitrosodiethylamine (NDEA)-induced hepatic tumorigenesis were investigated in Wistar rats. Experimental animals were divided into control, NDEA-treated, NDEA + garlic-treated, and garlic-treated. The characteristics of circadian rhythms (acrophase, amplitude, and mesor) of lipid peroxidation products (thiobarbituric acid reactive substances) and antioxidants (reduced glutathione, glutathione peroxidase, superoxide dismutase, and catalase) were analyzed. Alterations in the temporal characteristics of all variables were observed in NDEA-treated rats when compared to other groups. The alterations in the characteristics of these variables in NDEA-treated and in other groups deserve further investigation for the prognosis and therapeutic efficacy of chronotherapy of cancer.