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Abstract
Turnera aphrodisiaca. Ward (Turneraceae) has been traditionally used for the treatment of anxiety neurosis and as aphrodisiac, but no attempts have been made to investigate the plant systematically for its traditional claims. The current investigation was carried out ot isolate the bioactive constituent(s) from T. aphrodisiaca. using bioactivity-guided fractionation. Antianxiety activity-guided fractionation of methanol extract of the plant led to isolation of 5,7,4′ -trihydroxy flavone apigenin. Its structure was elucidated by UV and NMR data. Apigenin exhibited significant anxiolytic activity at a dose of 2 mg/kg, p.o., in mice using elevated plus maze model of anxiety. It is concluded that apigenin is responsible for anxiolytic effects of this traditionally used plant.