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Abstract
Decalepis hamiltonii Wight & Arn. (Asclepiadaceae) is widely used in the traditional system of medicine for many ailments. We examined the effectiveness of the methanol extract of roots of Decalepis hamiltonii at 250 and 500 mg/kg doses orally in the carrageenan-induced rat paw edema and cotton pellet–induced chronic inflammatory models. The extract showed significant dose-dependent anti-inflammatory activities in both models. The extract exhibited significant antipyretic activity at 250 and 500 mg/kg, p.o., in brewer's yeast–induced pyrexia.