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Abstract
The aim of the current study was to examine the antidiabetic action of Rubia cordifolia. Linn (Rubiaceae) aqueous root extract (RCAREt) in streptozotocin (STZ)-induced diabetic rat model. STZ-induced diabetic rats were treated with RCAREt for 8 weeks (1 g kg−1 b.w., orally per day). Serum glucose, total cholesterol and triglycerides, hematological parameters, and liver and kidney transaminases in normal, STZ diabetic, and RCAREt-treated diabetic rats were measured. The observed hyperglycemia, hypertriglyceridemia, enhanced transaminases of liver and kidney, hypochromic microcytic anemia, and loss of body weight in STZ diabetic rats were normalized by RCAREt treatment, whereas the hypercholesterolemia was not rectified. The beneficial effect of RCAREt treatment might be due to different types of active principles, each with a single or a diverse range of biological activities.